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Question of the Month – July 2024

On prenatal ultrasound, a fetus was noted to be small for gestational age. Cleft lip is present, as are overlapping digits with clinched fists on both hands. Rocker bottom feet are present, along with an atrial septal defect. Genetic analysis is returned showing complete trisomy of chromosome 18. Which of the following is true regarding Trisomy 18?
A. This condition was first described in 1892 by Dr John Hilton Edwards.
B. This is the most common autosomal trisomy syndrome.
C. This condition has a 3:1 female to male ratio for live births.
D. This syndrome occurs in 1:2500 live births.

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